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The intention of this study is to formulate the therapeutic advantage of the ketoprofen stable complex using a dextran-based biopolymer and to investigate the effect of the dextran on oral bioavailability of ketoprofen. Ketoprofen (2 mg kg-1), as a model drug, was administered with 0.5 g (1.34%) aqueous solution of dextran (DEX), to rats by oral and intravenous routes. The pharmacokinetic parameters and anti-inflammatory activity (ratio of inhibition of paw volume to basal level) were determined. The extent of inhibition of rat paw volume was determined at 4 h after administration of ketoprofen and the administration of the best formulation for intravenous and oral route, respectively. The ratio of inhibition of paw volume in intravenously treated rats showed that the DEX formulation was three times more effective than the pure ketoprofen. The pharmacokinetic parameters of the DEX formulation after oral administration were similar to those of ketoprofen, but the bioavailability was more than three times greater than that of the pure ketoprofen. These results demonstrate that the bioavailability of ketoprofen was increased in an aqueous solution of DEX, which may be attributable to the increase of the sol
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